منابع مشابه
Genetics of increased HDL cholesterol levels: insights into the relationship between HDL metabolism and atherosclerosis.
Astrong inverse association exists between plasma HDL cholesterol (HDL-C) levels and incidence of coronary artery disease.1 Although environmental factors play a role, variation in HDL-C levels are at least 50% genetically determined.2 The genetics of syndromes of very low HDL-C have been extensively studied. Mutations in apoA-I (the major HDL structural protein), ABCA1 (which promotes efflux o...
متن کاملEnhanced HDL Functionality in Small HDL Species Produced Upon Remodeling of HDL by Reconstituted HDL, CSL112
RATIONALE CSL112, human apolipoprotein A-I (apoA-I) reconstituted with phosphatidylcholine, is known to cause a dramatic rise in small high-density lipoprotein (HDL). OBJECTIVE To explore the mechanisms by which the formation of small HDL particles is induced by CSL112. METHODS AND RESULTS Infusion of CSL112 into humans caused elevation of 2 small diameter HDL fractions and 1 large diameter...
متن کاملAntiinflammatory Properties of HDL Genetics of Variation in HDl Cholesterol in Humans and Mice New Insights Into the Regulation of HDL Metabolism and Reverse Cholesterol Transport Endothelial and Antithrombotic Effects of HDL
Plasma high-density lipoprotein cholesterol (HDL-C) concentrations are genetically determined to a great extent, and quantitative trait locus (QTL) analysis has been used to identify chromosomal regions containing genes regulating HDL-C levels. We discuss new genes found to participate in HDL metabolism. We also summarize 37 mouse and 30 human QTLs for plasma HDL-C levels, finding that all but ...
متن کاملAntiinflammatory Properties of HDL Genetics of Variation in HDL Cholesterol in Humans and Mice New Insights Into the Regulation of HDL Metabolism and Reverse Cholesterol Transport Endothelial and Antithrombotic Actions of HDL
It is well recognized that high-density lipoprotein (HDL)-cholesterol is antiatherogenic and serves a role in mediating cholesterol efflux from cells. However, HDL has multiple additional endothelial and antithrombotic actions that may also afford cardiovascular protection. HDL promotes the production of the atheroprotective signaling molecule nitric oxide (NO) by upregulating endothelial NO sy...
متن کاملABCA1-deficient mice: insights into the role of monocyte lipid efflux in HDL formation and inflammation.
Studies with ATP-binding cassette transporter (ABCA1)-deficient mice have been critical in demonstrating the relation between ABCA1 expression, cellular lipid efflux, and HDL metabolism. The phenotype of the ABCA1-deficient mouse parallels the phenotype observed in human Tangier disease, including substantial reductions in both apolipoprotein B and apolipoprotein AI with confounding affects on ...
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ژورنال
عنوان ژورنال: Nature Reviews Endocrinology
سال: 2011
ISSN: 1759-5029,1759-5037
DOI: 10.1038/nrendo.2011.28